Ensembl Variant Effect Predictor (VEP)
VEP determines the effect of your variants (SNPs, insertions, deletions, CNVs or structural variants) on genes, transcripts, and protein sequence, as well as regulatory regions.
Simply input the coordinates of your variants and the nucleotide changes to find out the:- Genes and Transcripts affected by the variants
- Location of the variants (e.g. upstream of a transcript, in coding sequence, in non-coding RNA, in regulatory regions)
- Consequence of your variants on the protein sequence (e.g. stop gained, missense, stop lost, frameshift)
- Known variants that match yours, and associated minor allele frequencies from the 1000 Genomes Project
- SIFT and PolyPhen-2 scores for changes to protein sequence
- ... And more! See data types, versions.
VEP interfaces
Publication
If you use VEP, please cite our UPDATED publication so we can continue to support VEP development:
Cite us
VEP related tools
Variant recoder
Translate a variant identifier or HGVS notation to all possible variant IDs and HGVS
Command line (VEP): |
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REST API: |
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Haplosaurus
Computes observed transcript haplotype sequences based on phased genotype data
Command line (VEP): |
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REST API: |
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